Multi Organ Intervention State Space Code

A domain-specific language for clinical decision support and biotech workflow automation.

Install · Quick Start · Library · CLI · Full Manual

⚠️ RESEARCH USE ONLY
MOISSCode is a research prototype. It is NOT approved by FDA, CDSCO, or any regulatory body for clinical decision-making. Do not use MOISSCode output to make real patient care decisions. Aethryva Deeptech accepts no liability for clinical outcomes.

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What is MOISSCode?

MOISSCode is a domain-specific language designed for medical professionals and biotech engineers. Write clinical protocols in English-like syntax and let the engine handle scoring, drug classification, billing, lab interpretation, FHIR interoperability, and more.

protocol SepsisScreen {
    input: Patient p;

    let score = med.scores.qsofa(p);
    track p.lactate using KAE;

    if score >= 2 {
        administer Norepinephrine dose: 0.1 mcg/kg/min;
        alert "Sepsis detected!" severity: critical;
    }

    assess p for sepsis;
}

Installation

Requires: Python 3.10+

git clone https://github.com/aethryva/MOISSCode.git
cd MOISSCode

Windows (PowerShell):

py -m pip install -e .

macOS / Linux:

pip install -e .

Quick Start

Run a protocol file

moiss run examples/sepsis_workup.moiss -v

Validate syntax without executing

moiss validate examples/sepsis_workup.moiss

Interactive REPL

moiss repl

Embed in Python

from moisscode import MOISSCodeLexer, MOISSCodeParser, MOISSCodeInterpreter, Patient

code = """
protocol QuickCheck {
    input: Patient p;
    let score = med.scores.qsofa(p);
    if score >= 2 {
        alert "High risk" severity: critical;
    }
}
"""

lexer = MOISSCodeLexer()
tokens = lexer.tokenize(code)
parser = MOISSCodeParser(tokens)
program = parser.parse_program()

interp = MOISSCodeInterpreter()
interp.scope['p'] = {
    'type': 'Patient',
    'value': Patient(bp=85, hr=110, rr=24, temp=38.5, spo2=94,
                     weight=70, age=55, gcs=14, lactate=3.2, sex='M')
}

events = interp.execute(program)
for e in events:
    print(e)

Library Reference

MOISSCode ships with 20 built-in modules, all accessible via the med. prefix:

Module	Description
med.scores	12 validated clinical scores (qSOFA, SOFA, NEWS2, MELD-Na, CHA2DS2-VASc, HEART, Framingham, Child-Pugh, CURB-65, Wells PE, Glasgow-Blatchford, KDIGO AKI)
med.pk	Pharmacokinetic engine (100+ drugs, dosing, interactions, TDM, renal/hepatic adjustment)
med.lab	Lab panels (80+ tests, 15 panels, reference ranges, eGFR via CKD-EPI 2021)
med.micro	Microbiology (30 organisms, MIC breakpoints, 15 empiric therapy protocols)
med.genomics	Pharmacogenomics (8 CYP450 genes, 20 CPIC/DPWG guidelines)
med.biochem	Enzyme kinetics (25 enzymes), 8 metabolic pathways
med.epi	Epidemiology (SIR/SEIR models, R0, herd immunity)
med.nutrition	Clinical nutrition (BMI, BEE, TPN, IV fluids)
med.fhir	FHIR R4 bridge (Patient, Bundle, MedicationRequest)
med.db	SQLite persistence (patients, audit trail, alerts)
med.io	Device management (infusion pumps, monitors, ventilators, waveforms, alarms)
med.finance	CPT billing (38 codes) and cost tracking
med.research	De-identification, consent, randomization, sample size, stratification
med.glucose	Diabetes management (HbA1c, CGM analytics, insulin dosing, DKA, hypoglycemia)
med.chem	Medicinal chemistry (40 compounds, Lipinski, BCS, ADMET, toxicity screening)
med.signal	Biosignal processing (ECG peaks, HRV, SpO2, rhythm classification)
med.icd	Medical coding (94 ICD-10-CM codes, 25 DRG groups, SNOMED CT mapping)
med.papers	Scientific paper generation (LaTeX/PDF in IEEE, medRxiv, bioRxiv, JAMA, Nature, Lancet, PLOS)
med.kae	Kalman-Autoencoder state estimator for real-time vital sign tracking
med.moiss	MOISS intervention timing classifier (prophylactic to too-late)

CLI

moiss run <file.moiss> [-v]    Execute a protocol
moiss validate <file.moiss>    Parse-only validation
moiss repl                     Interactive shell
moiss version                  Print version

Language Features

• Protocols - protocol Name { ... }
• Patient input - input: Patient p;
• Variables - let x = expression;
• Conditionals - if condition { ... } else { ... }
• Loops - while condition { ... } and for item in list { ... }
• Custom types - type Bacteria { name: str; mic: float; }
• Functions - function calc(a, b) { return a + b; }
• Lists - let drugs = ["A", "B", "C"];
• Alerts - alert "message" severity: critical;
• Assessments - assess p for sepsis;
• Drug admin - administer Drug dose: 0.1 mcg/kg/min;
• Tracking - track p.lactate using KAE;

Project Structure

moisscode/
├── __init__.py       # Public API
├── cli.py            # CLI tool
├── lexer.py          # Tokenizer
├── parser.py         # AST parser
├── ast_nodes.py      # AST definitions
├── interpreter.py    # Runtime engine
├── typesystem.py     # Type checking + Patient
├── stdlib.py         # 20-module library
└── modules/          # Domain modules (med.*)

API Server

MOISSCode includes a REST API service for remote protocol execution.

Windows (PowerShell):

py -m pip install -e ".[api]"
py -m uvicorn moisscode.api.server:app --reload

macOS / Linux:

pip install -e ".[api]"
uvicorn moisscode.api.server:app --reload

See the moisscode/api/ directory for full API documentation and configuration.

Citation

If you use MOISSCode in research, please cite:

MOISS Framework:

Kunche, N. (2026). Multi-Organ Intervention State Space (MOISS): A Collision Geometry Framework for Quantifying Therapeutic Windows Across 10 Organ Systems in 301,470 ICU Patients. medRxiv. https://www.medrxiv.org/content/10.64898/2026.02.08.26345873v1

KAE Algorithm:

Kunche, N. (2025). The Kunche Adaptive Estimator: A Reliability-Adaptive Kalman Filtering Framework for Autonomous Multi-Biomarker State Estimation in Critical Care Monitoring. Authorea. https://doi.org/10.22541/au.176313985.55971071/v1

Contact

• Email: dev@aethryva.com
• Feature requests and bugs: GitHub Issues
• Creator: Nikhil Kunche
• Documentation: moisscode.com

License

BSL 1.1 - See LICENSE for details.