diff --git a/Lib/configparser.py b/Lib/configparser.py
index d435a5c2fe0da2..e76647d339e913 100644
--- a/Lib/configparser.py
+++ b/Lib/configparser.py
@@ -613,7 +613,9 @@ class RawConfigParser(MutableMapping):
         \]                                 # ]
         """
     _OPT_TMPL = r"""
-        (?P<option>.*?)                    # very permissive!
+        (?P<option>                        # very permissive!
+            (?:(?!{delim})\S)*             # non-delimiter non-whitespace
+            (?:\s+(?:(?!{delim})\S)+)*)    # optionally more words
         \s*(?P<vi>{delim})\s*              # any number of space/tab,
                                            # followed by any of the
                                            # allowed delimiters,
@@ -621,7 +623,9 @@ class RawConfigParser(MutableMapping):
         (?P<value>.*)$                     # everything up to eol
         """
     _OPT_NV_TMPL = r"""
-        (?P<option>.*?)                    # very permissive!
+        (?P<option>                        # very permissive!
+            (?:(?!{delim})\S)*             # non-delimiter non-whitespace
+            (?:\s+(?:(?!{delim})\S)+)*)    # optionally more words
         \s*(?:                             # any number of space/tab,
         (?P<vi>{delim})\s*                 # optionally followed by
                                            # any of the allowed
diff --git a/Lib/test/test_configparser.py b/Lib/test/test_configparser.py
index 1bfb53ccbb1398..d7c4f19c1a5ef0 100644
--- a/Lib/test/test_configparser.py
+++ b/Lib/test/test_configparser.py
@@ -2270,6 +2270,26 @@ def test_section_bracket_in_key(self):
         output.close()
 
 
+class ReDoSTestCase(unittest.TestCase):
+    """Regression tests for quadratic regex backtracking (gh-146333)."""
+
+    def test_option_regex_does_not_backtrack(self):
+        # A line with many spaces between non-delimiter characters
+        # should be parsed in linear time, not quadratic.
+        parser = configparser.RawConfigParser()
+        content = "[section]\n" + "x" + " " * 40000 + "y" + "\n"
+        # This should complete almost instantly. Before the fix,
+        # it would take over a minute due to catastrophic backtracking.
+        with self.assertRaises(configparser.ParsingError):
+            parser.read_string(content)
+
+    def test_option_regex_no_value_does_not_backtrack(self):
+        parser = configparser.RawConfigParser(allow_no_value=True)
+        content = "[section]\n" + "x" + " " * 40000 + "y" + "\n"
+        parser.read_string(content)
+        self.assertTrue(parser.has_option("section", "x" + " " * 40000 + "y"))
+
+
 class MiscTestCase(unittest.TestCase):
     def test__all__(self):
         support.check__all__(self, configparser, not_exported={"Error"})
diff --git a/Misc/NEWS.d/next/Security/2026-03-25-00-51-03.gh-issue-146333.LqdL__bn.rst b/Misc/NEWS.d/next/Security/2026-03-25-00-51-03.gh-issue-146333.LqdL__bn.rst
new file mode 100644
index 00000000000000..96d86ecc0a0fb3
--- /dev/null
+++ b/Misc/NEWS.d/next/Security/2026-03-25-00-51-03.gh-issue-146333.LqdL__bn.rst
@@ -0,0 +1,3 @@
+Fix quadratic backtracking in :class:`configparser.RawConfigParser` option
+parsing regexes (``OPTCRE`` and ``OPTCRE_NV``). A crafted configuration line
+with many whitespace characters could cause excessive CPU usage.